SYNTHESIS AND BIOLOGICAL EVALUATION OF 3- HYDRAZINYLQUINOXALINE2-(1H)-THIOL DERIVATIVES
Dharyappa Teli*, R. B. Kotnal, Sangappa Teli and S. M. Metri
Abstract
We have chosen molecules with moieties possessing the antimicrobial
activity of Quinoxaline derived from benzene. Its structure might be
obtained by replacing a (c-s) moiety with an oxygen atom. Which is
reported to have antibacterial and anti-Fungal activity and other
nitropyridine ring attached to the para position of the Quinoxaline ring
which possesses antibacterial, and antifungal activity. Present work
deals with the preparation of 3-Hydrazinylquinoxaline2-(1H)-thiol is
treated with hydrazine hydrate and nitropyridine gives 3-hydrazine-2-
[(3-nitropyridin-2-yl) sulfanyl]- 1,2-dihydro quinoxaline and 2- [(3-
hydrazine-1,2-dihydro quinoxaline-2yl) sulfanyl]-1- phenylethan-1-one. Hydrazides were
synthesized to increase intracellular concentration and to try and decrease the resistance
developed due to the decreased intracellular concentration of the drug these synthesized
compounds were subjected to preliminary biological evaluation. The characterization of
synthesized compounds was identified based on IR, 1HNMR, and Melting point. The
compounds have been evaluated for antimicrobial activity and Anti-Fungal activity.
Keywords: Quinoxaline, Antimicrobial activity, Anti-Fungal Activity, Intracellular concentration.
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