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Abstract

DESIGN AND IN-VITRO EVALUATION OF ORAL POROUS MATRIX TABLET FOR CONCOMITANT CONTROLLED RELEASE OF ANTI TUBERCULAR DRUGS

Dr. Santosh Payghan*, Dr. Sanjeevani Desai, A. J. Adhav and Vaishali Payghan

Abstract

Mycobacterium tuberculosis is a causative organism of tuberculosis, which is the most deadly disease after cancer in the current decade. The development of multidrug and broadly drug- resistant strains makes the tuberculosis problem more and more critical. The present study focused to develop an anti-tubercular (TB) fixed dose combination (FDC) tablet containing Rifampicin (RIF) and Isoniazid (INH) which would allow controlled delivery of RIF and INH. The preformulation studies were performed on RIF and INH, alone and in combination with excipients. The pharmacopoeia attributes of the FDC tablets were evaluated for Hardness, Friability, Weight variation and Thickness. The FDC matrix tablet was analyzed for the drug content and cumulative release of the drug. Fourier transform infrared, x-ray diffraction and differential scanning calorimetry results revealed that no relevant incompatibilities were identified in the kneaded system containing RIF, INH and Excipient. In vitro drug release from the FDC matrix tablet revealed that the polymer combinations rendered a cumulative dissolution of RIF and INH in acidic media with a controlled release pattern. The two polymer combinations used are found to be effective matrix for the release of both the drugs. This finding suggested that RIF and INH can be given by fixed dose combination by using two polymer combinations as matrix.

Keywords: Fixed dose combination, Rifampicin, Isoniazid, Controlled release tablet, Tuberculosis.


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