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Abstract

PREPARATION AND EVALUATION OF EZETIMIBE LOADED NANOPARTICLES BY SOLVENT EVAPORATION METHOD

J. Adlin Jino Nesalin, Sachith M. P.* and Manu Kumar M. S.

Abstract

The Ezetimibe loaded Eudragit S 100 nanoparticles were prepared by solvent evaporation technique. Nanoparticles of different core: coat ratio were formulated and evaluated for loading efficiency, particle size, zeta potential, solubility studies, in vitro drug release, kinetic studies and stability studies. The prepared nanoparticles have a particle diameter ranging approximately from 289-486 nm and a zeta potential of the ideal formulation FS4 is found to be 42 mV. There was a steady increase in the entrapment efficiency on increasing the polymer concentration in the formulations. The in vitro drug release profile of the formulation was in the range 70.2±1. to 94.8±1 % for 60 min (fig 6). The batch FS4 showed the fastest dissolution rate, with approximately 95% of the drug being released within 60 min. No appreciable difference was observed in the drug content of product which were stored at 5˚±3°C and room temperature (30º± 2ºC/65%RH), and 40± 2ºC/75%RH, (after 3 months storage (as per QA1(R)) of stability studies. According to the data obtained, this Eudragit S 100- based delivery system opens new and interesting perspectives as drug carriers.

Keywords: Nanoparticles; Eudragit S 100; Ezetimibe; Solvent evaporation, Solubility.


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