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Abstract

FORMULATION AND EVALUATION OF ATENOLOL ANTIHYPERTENSIVE BILAYER TABLET

Dr. G. Mariyappan* and L. Varsha

Abstract

The present investigation was focused on formulation and evaluation of Atenolol bilayer tablet which is used as antihypertensive agent. Bilayer tablet consist of two layer namely immediate release and sustained release. The Eight formulation of bilayer tablets were prepared by using different concentration of polymer. Immediate release layer was formulated by direct compression using polymers such as cross carmellose sodium, sodium starch glycolate. Meanwhile, sustain release was formulated by wet granulation using HPMC K15, chitosan and guar gum. Preparations of tablet were carried out by keeping the tablets weight as constant (350mg±20mg). And then characterization of prepared tablet was done by evaluation of hardness, friability, weight variation, drug content and in-vitro release of formulation (F1-F8). The precompression parameters of all formulation were studied like angle of repose, flow property, bulk density, tapped density, Carr’s index, Hausner’s ratio. The post compression parameters such as appearance, weight variation, uniformity of content of all formula were within the acceptable limits. The best formulations F8 was selected based on the thickness (3.41±0.01), hardness (6.3±0.17), friability (0.30±0.02), average weight (129,251), weight variation (1.5%) and drug content (99.16). The best formulation of Atenolol shows drug release was found to be F8 (89.95%). The in-vitro drug release kinetics showed that the formulation were compiles first order kinetics as correlation coefficient (r2)(0.934-0.985).

Keywords: Bilayer tablet, sodium starch glycolate, HPMC K15, In-vitro dissolution release.


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