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Abstract

PHARMACOVIGILANCE: A STATISTICAL STUDY OF ADVERSE DRUG REACTIONS OF ANTIHYPERTENSIVE AND ANTIDIABETIC DRUGS IN GADHINGLAJ RURAL REGION

Omprakash P. Jadhav, Sonu B. Tandale*, Aniket C. Suryawanshi, Renuka M. Yejare, Sadhana R. Bamane and Renuka G. Bansode

Abstract

Adverse drug reactions to drugs are the curse of drug development and can lead to life-threatening illnesses. which then causes the discontinuation of therapy. ADR of drugs can affect not only patients' health but also other health professionals and pharmaceutical companies. The main aim of this study is to find the ADRs in hypertension and diabetes disease. Hypertension is seen to be the most common condition but can lead to serious conditions like myocardial infraction, stroke, renal failure, and death if it is not treated at the right time. Diabetes is caused due to the production of an insufficient amount of insulin or due to a poor body response to the insulin that is made by the pancreas. This study is important because ADRs of hypertension and diabetes drugs help to reduce or overcome the damage caused by taking medication for the treatment of specific disease conditions. The survey was conducted in Gadhinglaj rural areas (villages). First of all, we selected the hospitals where hypertensive and diabetic patients are treated. In this survey, we interacted with doctors to collect information about adverse drug reactions found in patients who are taking antihypertensive and antidiabetic medications. After completing the survey, we know which drugs have the most adverse drug reactions. We also find out which ADRs are frequently experienced. All the data we gathered here is used by a non-parametric test, i.e., by the Kruskal-Wallis Test. To observe the null hypothesis, we determine the rejected null hypothesis. We came to the conclusion that hypertensive and diabetic patients require extensive care and therapy, as well as good counselling. In the case of antihypertension, amoxetine, a calcium channel blocker, is the primary medicine of choice, indicating the majority of ADRs when compared to other pharmacological classes. In the case of anti-diabetic drugs, we learn that metformine is the most commonly used, but it has more ADRs such as edema.

Keywords: Pharmacovigilance, Antihypertensive, Antidiabetic, Adverse drug reaction.


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