WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
Best Paper Award :
Dr. Dhrubo Jyoti Sen
Download Article: Click Here

Search

Track Your Article

Abstract

FORMULATION AND EVALUATION OF METFORMIN HCL EFFERVESCENT FLOATING TABLETS

Umadevi Uppara*, Dr. K. Muniraja Lakshmi, Dr. AppaRao Chippada

Abstract

The aim of the present study involved the formulation and evaluation of metformin hydrochloride effervescent floating tablets. Two hydrophilic polymers are used at various concentrations (10, 12.5, 15 and 17.5%), xanthum gum and hydroxypropylmethylcellulose (HPMC) at three viscosity grades (K4M, K15M and K100M). The results have shown the effect of nature of hydrophilic polymer on the biopharmaceutical behavior of metformin HCl floating tablets. The prepared tablets were evaluated for number of parameters like Thickness, Hardness, Weight variation, Friability, Drug content uniformity, Floating lag time, Floating time and in vitro release studies. The drug release kinetic was found to be dependent on HPMC viscosity, particularly at the concentration 17.5%. The floating tablets F8 (HPMC K15M) and F12 (HPMC K100M) have exhibited extended release kinetics (>8 hours) with release rates of 92.18+1.09 and 80±1.14% respectively.

Keywords: Metformin HCL, HPMC, Xanthum Gum, Granulation.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More