WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
Best Paper Award :
Dr. Dhrubo Jyoti Sen
Download Article: Click Here

Search

Track Your Article

Abstract

PHARMACOLOGICAL EVALUATION OF ANTIDEPRESSANT-LIKE EFFECT OF VITAMIN E AND ITS COMBINATION WITH AMITRIPTYLINE: AN ACUTE STUDY

Rajas R. Jadhav*, Vitthal J. Chaware and Vivekkumar K. Redasani

Abstract

Aim: The aim of the study to evaluate anti-depressant like effect of Vitamin E and its combination with amitriptyline against reserpineinduced depression in rats. Materials and Methods: Reserpine was injected to induce depression in all rats except normal control group. All animals were divided randomly into six groups (6 rats each); Group-I received Vehicle; Group-II received Reserpine; Group-III received Amitriptyline; Group-IV received Vitamin E; Group-V and VI received combination of Amitriptyline and vitamin E. Forced swim test and Actophotometer were used to assess anti-depressant activity. Result: In locomotor activity testing, locomotor activity count was found to be increased, when animals were treated with a combination of amitriptyline and vitamin E i.e amitriptyline (5mg/kg) with vitamin E (50mg/kg) and amitriptyline (10mg/kg) with vitamin E (50mg/kg). In forced swim test, latency to immobility time and duration of immobility time was found to be increased and decreased respectively, when animals were treated with a combination of Amitriptyline (5mg/kg) with vitamin E (50mg/kg) as well as amitriptyline (10mg/kg) with vitamin E (50mg/kg). Conclusion: Vitamin E showed potentiation and synergistic anti-depressant effect with amitriptyline.

Keywords: Depression, Antidepressant activity, Forced swim test, Reserpine, Vitamin E, Locomotor Activity.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More