Abstract

NANOSUSPENSION: A PROMISING DRUG DELIVERY SYSTEM FOR POORLY WATER-SOLUBLE DRUGS AND ENHANCED BIOAVAILABILITY

*Eswarappa Nandini (B Pharm), Dr. Beny Baby, Suprem Kumar Suryawanshi (B Pharm) and Kumaran S. (B Pharm)

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Abstract

Nanosuspension consists of a submicron colloidal dispersion of particles of the active ingredient of the medicine. Liquid phase stabilized by surfactant. Poor water solubility is a major problem in the manufacture of formulations. Decreased active ingredient particles lead to increased surface area and bioavailability. Nanosuspensions are manufactured in several ways. Techniques such as media milling and high pressure homogenization have been used commercially to prepare nanosuspensions. Recently, emulsions and microemulsions have been used as templates for the development of nanosuspensions. The unique properties of nanosuspensions allow it to be used in a variety of dosage forms and are administered by a variety of routes. B. Orally, as lung, eye, topical and mucosal adherent hydrogels. The advantages of nanosuspension are improved drug dispersibility and solubilization, improved therapeutic effect, and reduced toxicity. Therefore, this review describes the results of nanosuspension in drug delivery systems to improve drug solubility, stability, and bioavailability. This review describes how to prepare nanosuspensions, characterize them, and apply them.

Keywords: Nanosuspensions are manufactured in several ways.