Abstract

FORMULATION, EVALUATION AND CHARACTERIZATION OF NARINIGN LOADED MICROPARTICLES USING ACACIA NILOTICA GUM

Anuj Sharma* and Atul Kaushik

.

Abstract

The objective of the work was to purify natural polymer (Acacia nilotica gum) and formulate Naringin loaded microspheres using sodium alginate and Acacia nilotica gum. The microspheres were prepared by ionic gelation method using fixed concentration of sodium alginate and varying amounts of Acacia nilotica gum. The average percentage yield of all batches ranged from 59.4 to 78.4% suggesting that ionic gelation technique is suitable for microspheres preparation. The average particle size of the formulations ranged from 26.4 ± 16.025 μm to 30.58 ± 10.724 μm. The drug content of the microsphere formulations ranged from 63.50 to 86.17%. The drug release ranged from 42.18 to 98.77% from the microsphere formulations at the end of 6 hours of the study. From the overall results obtained for drug content, particles size and micromeritic properties it could be concluded that the formulation F4 containing sodium alginate and Acacia nilotica gum in the ratio 1:1.25 was the best formulation.

Keywords: Naringin, Microsphere, Ionic gelation, Sodium alginate, Acacia nilotica gum.