Abstract

WHOLESOME DIET AND GUTMICROBIOME, SPECIAL FOCUS ON BUTYRATE; A CRITICAL REVIEW ON ITS MODULATORY EFFECT ON -GUT HOMEOSTASIS IN MALABSORPTION W.S.R TO GRAHANI

Ajeesh C.C.* and P. Gourisankar

.

Abstract

Malabsorption is a leading cause for nutritional deficiency disorders. An imbalanced microbiome has been associated with a number of gastrointestinal diseases including irritable bowel syndrome and inflammatory bowel disorder. Dietary fibre is rich source of food for gut bacteria and its reduction can lead to a decreased bacterial production of short chain fatty acid butyrate. This change can lead to dysbiosis and local inflammation in the gut lining, resulting in impaired gut barrier function and the possible leakage of bacterial toxins into the blood stream. Malabsorption refers to impaired nutrients absorbed and maldigestion within the brush border epithelium of gastro intestinal tract. As gastrointestinal tract is the primary organ provided to diet sections, diet may be regarded as one of the essential factors in the functionality, integrity, and composition of intestinal microbiota. The gut microbiome participates in the absorption of the host’s nutrients and metabolism, maintains the microcirculation, and modulates the immune response. By the consumption of ama, virudha like aharas will affect the agni and there causes agnimandya and leads to diseases there by improper absorption and assimilation will takes place and leads to grahani.

Keywords: Ama, Grahani, Agni.