Abstract

TO INVESTIGATE ANTI-DIABETIC POTENTIAL OF MARTYNIA ANNUA LINN. FLOWER EXTRACTS IN WISTAR RATS

Saiyad Moinali F*, Gohil Kashmira J.

Department of Pharmacology, Shree Dhanvantary Pharmacy College, Kim - 394110, Dist. Surat, Gujarat, India

Abstract

Diabetes mellitus is a metabolic disorder of multiple aetiology characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. Present study aimed to investigate the antidiabetic activity of methanolic extracts of Martynia annua Linn. (MEMA) in streptozotocin (STZ) and Streptozotocin-Nicotinamide (STZ-NIC) induced diabetes in Wistar rats. Male, albino Wistar rats were divided into five groups each group contain 5 animals. Diabetes was induced by STZ (55 mg/kg, p.o) and STZ-NIC (55,110 mg/kg, p.o). MEMA (200 mg/kg, 400 mg/kg) were administered to diabetic rats for 21 days. The effects on blood glucose, glycosylated haemoglobin, high density lipoprotein (HDL), and triglyceride were studied in diabetic rats. MEMA showed good reductions in blood glucose, triglyceride and glycosylated haemoglobin levels and increased HDL levels in diabetic rats in dose dependent manner after 21 days. MEMA showed a good antidiabetic activity in STZ and STZ-NIC induced diabetic rats. Further research is sought to explore the exact mechanism of action and phytoconstituents responsible for the antidiabetic activity.

Keywords: Martynia annua, Streptozotocin, Nicotinamide, Antidiabetic activity.