Abstract

EVALUATION OF ANTI-OSTEOARTHRITIC ACTIVITY OF METHANOLIC EXTRACT OF CYNODON DACTYLON IN MONOSODIUM IODOACETATE INDUCED RATS

Mrunal Ghag Sawant*, Anjana Kalpesh Yadav and Sheetal Sudhakar Shetty

Abstract

Osteoarthritis is a common condition and is likely to become even more prevalent as the population ages. It involves focal areas of damage to the articular cartilage of synovial joints, with subsequent remodeling of the underlying bone and mild synovitis. Medicinal Plants are source of various potent and powerful drugs one such plant is Cynodon dactylon Linn. The plant contains flavonoids, glycosides, and alkaloids. Few studies on pharmacological activity of this plant such as toxicity studies, anti-diabetic, antiulcer, diuretic, antimicrobial, hepatoprotective, cardio protective, immunomodulatory, antiinflammatory, rheumatoid arthritis can be found in scientific literature. Thus its activity as anti-inflammatory and rheumatoid arthritis could be further explored for it activity in Osteoarthritis. The present investigation was undertaken to demonstrate the activity of C. dactylon in intra articularly induced Osteoarthritis using Monosodium Iodoacetate induced animal model.

Keywords: Anti-inflammatory, Osteoarthritis, Monosodium Iodoacetate, Medicinal Plants, Cynodon dactylon, Methanolic Extract.