Abstract

PHYSIOCHEMICAL CHARACTERIZATION OF AN ANTIINFLAMMATORY TRANSDERMAL PATCHES CONTAINING NOVEL POLYHERBAL FORMULATION ANPG

Sakkariya K. N.*, Habeebulla M. V., Jisha Dev, Fathima P. V., Jubairiyya N., Hashim N. K. and Muhamned Kutty P. V.

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Abstract

A quite a large number of plant components have lipophilic properties, and many attempts have been made to overcome this. The administration of biologically active phytochemical compounds via the transdermal route is a possible solution to above mentioned problem. A transdermal patch is used to deliver medication through the skin. An adhesive patch containing medication is placed onto the skin, and a specified dose is then absorbed through the skin and into the bloodstream. Pharmaceutical scientists explore several strategies for the formation and stabilization of transdermal patches in modern medicines and they can be applied to polyherbal formulations too. In this paper, a matrix diffusion transdermal drug delivery system was designed and developed for extended delivery of Ayurgreen Natura Pain Gel ANPG polyherbal formulation using various combinations of polyvinyl pyrrolidine- K30 (PVP) and poly vinyl alcohol (PVA) and to their crosslinked form because of ease of fabrication. The ANPG matrix patches were tested for their physiochemical characterization by Fourier transform infrared spectroscopy (FTIR), UV-Vis spectroscopy, differential scanning calorimetry (DSC), and X-ray diffraction (XRD). The characterizations showed the homogeneous patches without the crystal form of the phytochemical constituents in matrix patches. The weight of transdermal patches of ANPG (2 cm2; 0.4 g/patch) and was found to be 0.235+0.001 gm and its thickness was found to be satisfactory with high drug content.

Keywords: Transdermal Patch, Polyherbal formulation, Polymers, PVP-K30, PVA.