Abstract

EXAMINATION OF IN VITRO ANTIVIRAL ACTIVITY OF AQUEOUS EXTRACT OF SMILAX CHINA RHIZOME

Apada Reddy Gangadasu* and Rakesh Jat

Abstract

Phytochemicals are secondary plant metabolites that are ecologically derived from plants. Plants develop phytochemicals in order to protect themselves against environmental stress and invasions by harmful microorganisms. It is well established that the phytochemical substances in question can provide therapeutic as well as pharmacological effects on human diseases. It is a well-established fact that the active elements that are found in medicinal plants work together in a synergistic manner to alleviate the primary and secondary difficulties that are associated with a number of different ailments. For the treatment of new Corona virus infections, Smilax china is frequently utilized both as a pharmaceutical agent and as a dietary supplement (COVID-19). In the current investigation, the aforementioned plant is examined to determine whether or not it inhibits the binding of SARS CoV-2 spike protein (RBD) to Human ACE-2 receptors. The findings demonstrated that the aqueous extract has considerable suppression of COVID 19 spike protein when combined with human ACE-2. The data that were presented provide scientific evidence for the antiviral activity, with inhibition of viral entry and therapeutic efficacy. This antiviral activity, inhibition of viral entry, and therapeutic efficacy may be, in turn, due to the presence of biologically active molecules present in the medicinal plant Smilax china.

Keywords: Smilax china; in-vitro antiviral activity, covid 19, SARS COV2, SARS COVID.