Abstract

PHARMACOGNOSTICAL AND PHARMACEUTICAL ANALYSIS OF PANCHATIKTAGHRITA GUGGLU AN AYURVEDIC POLYHERBAL FORMULATION

Atul Joshi*, Prof. Dr. Anup Thakar and Dr. C. R. Harisha

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Abstract

Background: Panchatikta Ghrita Guggulu is a polyherbal formulation mentioned in Ashtanga Sangraha containing various Ayurvedic medicinal drugs and specially indicated for the treatment of Asthi- Sandhi-Majjagata Vata. For assurance of quality of herbal compounds pharmacognostical and pharmaceutical analysis should be done. Methods: Panchatikta Ghrita Guggulu was subjected to microscopic evaluation for Pharmacognostical study, physiochemical analysis like hardness, weight variation, loss on drying, ash value, acid insoluble extract, pH value, water soluble extract, alcohol soluble extract, high performance thin layer chromatography (HPTLC). Results: Pharmacognostical study showed the presence of certain identifying characters of all of the ingredients of Panchatikta Ghrita Guggulu that is Nimba, Guduchi, Patola, Kantakari, Vasa, Gugglu, Patha, Vidanga, Devadaru, Gaja Pipalli, Yavakshra, Sarjikshara, Shunthi, Haridra, Mishi, Chavya, Kushtha, Tejovati, Maricha, Kutaja, Yavani, Chitraka, Katurohini, Bhallataka, Vacha, Pipallimoola, Rasna, Manjishtha, Ativisha, Goghrita. In pharmaceutical study, preliminary physiochemical analysis showed that hardness of the Vati was 4.05 Kg/cm2, ash value 5.83% w/w, loss on drying 9.89% w/w, water soluble extract 23.9% w/w, alcohol soluble extract 32.7% w/w and HPTLC showed 8 spots in 254nm and 5 spots in 366nm. Conclusions: Present work was carried out to standardize the polyherbal formulation Panchatikta Ghrita Guggulu in terms of its identity, quality and purity. Pharmacognostical and physico-chemical observations revealed the specific characters of all active constituents in the preparation were present in it.

Keywords: Panchatikta Ghrita Gugglu, Pharmacognosy, Pharmaceutics.