Abstract

EXPRESSION OF PROGESTERONE RECEPTORS ON BENIGN AND MALIGNANT SALIVARY GLAND TUMORS- AN IMMUNOHISTOCHEMICAL STUDY

Dr. Kriti Sao*, Dr. Sharada P., Dr. Ashwini B.K.

.

Abstract

Salivary gland tumors are the most heterogenous group of tumors histologically with greatest diversity of morphologic features among their cells and tissues. As both the salivary gland and breast tissue share a common histological pattern of tubule-acinar unit, their similarity with certain breast tumors is possible. The importance of hormone receptor status in breast cancer has been pivotal in determining prognosis and likelihood of response to hormonal manipulation. Tumors which are both ER and PR positive are much more likely to respond to anti-ER and anti-PR therapy than ER and PR negative tumors. The expression of sex hormone receptors in some tumors suggests a role for these receptors in tumor pathogenesis and therapy. Hence an attempt has made to IHC expression of PR protein in benign and malignant salivary gland tumors and to compare the expression between benign and malignant SGTs.

Keywords: Tumours, expression, response, IHC.