Abstract

AN ACUMEN INTO ANTICANCER EFFICACY OF IMIDAZOLE DERIVATIVES: A REVIEW

M. Shaquiquzzaman, Sumit Kumar Kaushik, Mymoona Akhter, Mohemmed Faraz Khan, Fatima Arshad, Akranth Marella*, Tarique Anwer, Wasim Akhtar, Shaista Amin and Mohammad Mumtaz Alam*

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Abstract

Imidazole, a 1,3-dinitrogen containing five membered heterocyclic ring, is constantly attracting scientists towards its various medicinal properties. Imidazole elicits various pharmacological properties such as antibacterial, analgesics, anti-HIV and anti-cancer etc. It is a part of many marketed formulations where it is used as an antifungal drug (e.g., Clotrimazole, Bifonazole etc.). Much lately a lot of work has been done in the towards determining the anticancer propensity of the imidazole ring. The present review covers the work done in the recent years by various researchers towards its anti-cancer acumen.

Keywords: Heterocyclic; Imidazole; Pharmacological Activity; Anticancer, 1,3-dinitrogen, Antifungal.