Abstract

A COMPREHENSIVE REVIEW ON FORMULATION AND EVALUATION OF FAMOTIDINE FLOATING TABLETS USING TAMARIND SEED GUM

M. V. Sudharani*, Cheboina Mounika, Indupriya Juvvaladinne

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Abstract

The goal of this project was to create a famotidine floating medication delivery device. Poor famotidine absorption in an acidic environment (upper GIT). The bioavailability when administered orally is close to 50%. The current study was conducted to look at the floating dose form of famotidine in an effort to get over these difficulties. Direct Compression was used to create floating tablets. Six formulations with varying ratios of the retardant (Na-CMC) and the gel-forming agent (HPMC K4M) were created. Its gas-generating substance (NaHCO3) combines with HCl to release CO2, which makes holes in the tablet, increases swelling, and keeps the tablet from disintegrating. The main structural polysaccharide in the primary cell wall of higher plants is xyloglucan. The looseness of a fine network of cellulose microfibrils regulates cell growth and expansion. These cellulose microfibrils are crosslinked by xyloglucan, giving them the flexibility needed for sliding. TSP (Tamarind Seed Powder) acts as TSG (Tamarind Seed Gum) and have good disintegrating and good adhesive property.

Keywords: TSG, TSP, famotidine, adhesive, disintegrating property.