WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
Best Paper Award :
Dr. Dhrubo Jyoti Sen
Download Article: Click Here

Search

Track Your Article

Abstract

SYNTHESIS, CHARACTERIZATION AND IN-VITRO ANTIINFLAMMATORY AND ANTI OXIDANT ACTIVITY OF SOME NOVEL CHALCONE BASED ACETAMINOPHEN DERIVATIVES

*M. Loganathan, K. S. Dinesh, V. Prabhakar and Dr. A. Chithra and M. Muthuraj

Abstract

Chalcones are the naturally occuring flavanoid compounds which are now becoming trend in synthetic research because of its wider pharmaceutical application. Chalcones and their derived products are known to possess variety of biological activities such as antimicrobial, anticancer, antitubercular, antioxidant, anti-inflammatory, antileishmanial, enzyme inhibitory acquiring an unique place in medicinal chemistry. In the present study, chalcones based compounds are synthesized by claisen schmidt reaction using acetaminophen and various aldehydes to get the title compound. Four different compounds are formed using different aldehydes like chromene 3 carbaldehyde, para Anisaldehyde, furfuraldehyde, formaldehyde. The compounds formed are characterized by IR spectroscopy and NMR spectroscopy and evaluated for invitro anti oxidant activity using DPPH radical scavenging assay and anti inflammatory activity by Inhibition of albumin denaturation. From the studies it was concluded that the compound formed from chromene 3 carbaldehyde shows maximum inhibition of albumin denaturation and anti oxidant activity.

Keywords: chalcones, aldehydes, acetaminophen, anti inflammatory, anti oxidant.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More