Abstract

SYNTHESIS, CHARACTERIZATION AND IN-VITRO ANTIINFLAMMATORY AND ANTI OXIDANT ACTIVITY OF SOME NOVEL CHALCONE BASED ACETAMINOPHEN DERIVATIVES

*M. Loganathan, K. S. Dinesh, V. Prabhakar and Dr. A. Chithra and M. Muthuraj

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Abstract

Chalcones are the naturally occuring flavanoid compounds which are now becoming trend in synthetic research because of its wider pharmaceutical application. Chalcones and their derived products are known to possess variety of biological activities such as antimicrobial, anticancer, antitubercular, antioxidant, anti-inflammatory, antileishmanial, enzyme inhibitory acquiring an unique place in medicinal chemistry. In the present study, chalcones based compounds are synthesized by claisen schmidt reaction using acetaminophen and various aldehydes to get the title compound. Four different compounds are formed using different aldehydes like chromene 3 carbaldehyde, para Anisaldehyde, furfuraldehyde, formaldehyde. The compounds formed are characterized by IR spectroscopy and NMR spectroscopy and evaluated for invitro anti oxidant activity using DPPH radical scavenging assay and anti inflammatory activity by Inhibition of albumin denaturation. From the studies it was concluded that the compound formed from chromene 3 carbaldehyde shows maximum inhibition of albumin denaturation and anti oxidant activity.

Keywords: chalcones, aldehydes, acetaminophen, anti inflammatory, anti oxidant.