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Abstract

FORMULATION AND EVALUATION OF ORAL DISPERSIBLE TABLETS OF STAVUDINE WITH DIFFERENT SUPER DISINTEGRANTS

Sindhu A. C.*, Madhu Kumar M. T., Bhanushree S., Sinchana R. and Jinu Joseph N. R.

Abstract

The main aspiration of these research works the oral fast disintegrating tablets of stavudine were prepared by apply of natural or synthetic super disintegrants by direct compression method. At the beginning stage preformulation studies were carried out to examine physiochemical properties of the drug and compatibility with additives. Six formulations are prepared and assess for minimum achievable dispersion time to optimize the excellent formulation. Initial three formulations contain synthetic disintegrant that is crospovidone and remaining three formulation contains natural super disintegrants that is guar gum. The formulation was evaluated for impact of super disintegrating on tablet, weight variation, hardness, thickness, drug content uniformity, friability, dispersion time, and in-vitro release studies. The results were announced that tablet containing 15% crospovidone (F3) showed short disintegration time (12) with maximum drug release (99.2%) in 15 min. DSC and FTIR results showed no evidence of interaction between the drug and superdisintegrants. This result shows that effect of formulation processing variables on tablet properties. On the basis of results the oral fast disintegrating tablets of stavudine could be prepared by direct compression method using crospovidone as superdisintegrant.

Keywords: Oral fast disintegrating, Superdisintegrants, Crospovidone, Guar gum, stavudine, Dispersion time etc.


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