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Abstract

FORMULATION, CHARACTERIZATION AND EVALUATION OF MICROCAPSULE OF SAXAGLIPTIN

Jang Bahadur Yadav, Abhishek Kumar Yadav, R. S. Kushwaha*, Sushmita Vishwakarma, Awadhesh Kumar Yadav and Mohd. Shawal Raza

Abstract

The present study was carried out to develop Saxagliptin drug delivery System in the form of Microcapsule dosage form of Saxagliptin by using EC and HPMC and thereafter formulating the formulation. From the study it is observed that formulation act as prolonged dosage form. As the stirring speed increased the size of Microcapsule decreases and increases the released rate drug. The prepared microcapsule of saxagliptin also gave good percent yield, drug entrapment and In- vitro release. The Microcapsules of F3 batch were found to be satisfactory in terms of percent yield, percent drug entrapment and In-vitro release. Prepared Microcapsule were evaluated for measurement of mean particle size determination of zeta potential, percentage yield, drug entrapment, shape and surface characterization of Microcapsules by scanning electron microscopy (SEM), Floating time, In-vitro release studies, and drug release kinetic data analysis. The mean size of the Microcapsules was determined by photo correlation spectroscopy (PCS) on a submicron particle size analyzer (Horiba Instruments) at a scattering angle of 90°. A sample (0.5mg) of the Microcapsules suspended in 5 ml of distilled water was used for the measurement. The results of measurement of mean particle size found: 128.4nm. The zeta potential of the drug-loaded Microcapsules was measured on a zeta sizer (Malvern Instruments) by determining the electrophoretic mobility in a micro electrophoresis flow cell. All the samples were measured in water at 25°C in triplicate. Results of zeta potential of optimized formulation F3 found: - 35.69 mV. The maximum Percentage Yield, Drug Entrapment, Percentage Buoyancy and floating lag time was found to be formulation F3 in floating Microcapsule. The optimized formulation of both batches subjected to further studies.

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