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Abstract

DETERMINATION OF ETORICOXIB IN BULK FORMULATIONS BY RP-HPLC METHOD

Aayushi Agarwal Bansal*

Abstract

For the determination of Etoricoxib in bulk formulations a rapid, selective and simple RP-HPLC method was formed and used, by optimizing stationary phase, composition of mobile phase and other parameters. Study was performed on RP- C-18 (250 x 4.6 mm), 5 μm column (Symmetry, Waters) with the mobile phase Acetonitrile: Phosphate buffer in the ratio of 70:30 v/v. At a flow rate of 1 ml/ min, the mobile phase was pumped and the detection was monitored at 220 nm. Short retention time was observed of the drug i.e. 9.589 min. The calibration curve was linear from 70ppm to 130 ppm and correlation coefficient of 0.998144. The intra-day precision (%RSD) was 0.99 and inter-day precision (% RSD) was in the range 0.99 to 1.21. The assay was found to be 99.28 %. The above method was successfully used for the assay of etoricoxib in bulk formulations.

Keywords: Etoricoxib, RP-HPLC, Assay, Bulk formulation.


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