SYNOVIAL MUCOSAL CYTOKINES AND CHAPEROKINE IN STAPHYLOCOCCUS AUREUS HUMAN SEPTIC A RTHRITIS
Ibrahim M S Shnawa*, Esraa Aa Aljenaby, Hamad A Busisi and Iiyad F Al Aga
Abstract
Human septic arthritis were clinically proven by the orthopedician in
this team. S. aureus was reported in association of 27 neutrophilic
synovitis out of 400 arthritis patients. Such patient infections induces
local production of synovial cytokines TNF alpha, INF gamma, IL4
and the chaperokine heat shock protein HSP 70 to high levels than that
of controls. The proinflammatory; TNF alpha, INFgamma, balanced by
the anti-inflammatory IL4 and HSP70 representing the TH1/TH2
balance state. Hence, S. aureus initiate natural neutrophilic, humoral
and cellular responses in the synovial compartment of the common
mucosal immune system during the septic human arthritis.
Keywords: Septic arthritis, synovum, common mucosal immune system, TH1/TH2 balance.
[Full Text Article]