Abstract

ASSESSMENT OF SENSITIVITY PATTERN OF ANTIMICROBIALS PRESCRIBED IN ONCOLOGY DEPARTMENT OF A TERTIARY CARE HOSPITAL

*Ashwin Sony, Thenzin V. Jubil, Aswin V. Aji, Anjo Varkey, Dr. Rini Susan Varghese, and Dr. Renoy Philip

Abstract

Background: Antimicrobials are prescribed empirically and prophylactically without performing culture sensitivity tests. However, inappropriate prescribing pattern of antibiotics directs to increase in mortality, medical expenses and drug-resistant strains of bacteria. Antibiotic therapy on the initial use in febrile neutropenia episodes should be based on local bacterial susceptibility and sensitivity pattern to prevent failure of treatment with increased morbidity and mortality. This prospective study describes the antimicrobial sensitivity pattern of common organisms in isolates of clinical samples of oncology patients. Objectives: • To assess the antimicrobial sensitivity pattern of common organisms in clinical samples of neutropenic and nonneutropenic patients admitted in oncology department. Method: The proposed prospective study was conducted over 145 patients of Oncology department in Aster CMI hospital, Bangalore for duration of 6 months. Result: A total of 145 patients were included in the study. Out of 145, 82 patients were male and female consisted of 63 sample. 76.6% of the population was found to be non-neutropenic and 23.4% was neutropenic. Gram negative bacteria showed high resistance to ciprofloxacin and cefuroxime. Aminoglycosides like gentamycin exhibit resistance to gram positive bacteria. Conclusion: The data was collected to identify the resistance pattern of antimicrobials. Antibiotic therapy on the initial use in febrile neutropenia episodes should be based on local bacterial susceptibility and sensitivity pattern to prevent failure of treatment with increased morbidity and mortality.

Keywords: Neutropenia, non-neutropenia, cancer.