THE POSSIBLE BENEFICIAL EFFECTS OF SELENIUM SUPPLEMENTATION IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA USING FINASTERIDE
Haidar Kadhim Al-Jawadi*, May S. Al-Sabbagh and Yousuf M. Al-Hallaq
Abstract
Background: Aging in human males leads to imbalance between
reactive oxygen species (ROS) formation and antioxidant capacity in
favor of increasing the former which lead to benign prostatic
hyperplasia (BPH). Selenium, a trace element, is found to possess
antioxidant properties due to its involvement in the glutathione
peroxidase enzyme. Objective: This study was implemented to
evaluate the clinical and biochemical beneficial effects of selenium
supplementation to improve the clinical and biochemical outcome
parameters in a sample of Iraqi patients suffering from benign prostatic
hyperplasia (BPH) using finasteride. Methods: Seventy individuals
were enrolled in this study. Ten normal healthy individuals were set as
a baseline. Twenty patients with BPH on finasteride 5mg daily were
followed up for 3 months and considered as the control group. Forty
other patients with BPH on finasteride 5mg daily were given selenium
200μg daily and followed up for the same 3 months. Biochemical and clinical parameters
were reported monthly for the patient and control groups. They were serum prostate specific
antigen (PSA), serum malondialdehyde (MDA), serum selenium level, international prostate
specific score (I-PSS), and post-voidal residual volume (PVRV). Results: It was found that
the group taking selenium showed a decrease in serum PSA and serum MDA and PVRV as the selenium level was increased. The I-PSS score also showed a decrease as serum selenium level increased. Conclusion: Selenium has a beneficial effect on biochemical parameters in these patients attributed to its antioxidant properties; hence the clinical parameters also showed improvement.
Keywords: selenium, antioxidant, benign prostatic hyperplasia
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