Abstract

A REVIEW ON: TRANSETHOSOMES AS NOVEL VESICULAR CARRIERS FOR TRANSDERMAL DRUG DELIVERY

Mohammed Muzammil*, Nagaraja T. S., Yogananda R., Abubaker Siddiq, Maruthi N., Snehalatha and Rakshitha YA.

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Abstract

Transdermal drug delivery is the non-invasive delivery of medications from the surface of skin which is the largest and most accessible organ of human body through its layers to the circulatory system. Transdermal drug delivery offers many advantages over conventional injection and oral methods but the skin, particularly stratum corneum acts as a barrier to most drug absorption, so novel vesicular drug delivery systems such as liposomes, niosomes, ethosomes, transferosomes and transethosomes has been developed to overcome this limitations and to improve the transport of drugs through the skin. Transethosomes are the attempt to combine the advantages of classical ethosomes with deformable liposomes (Transferosomes) in one formula. Transethosomes are composed of phospholipids, ethanol, penetration enhancer or an edge activator and water. The penetration rate of the skin is increased by ethanol and the drug is delivered into the deeper layers of skin. These transethosomal systems are more efficient in drug delivery when compare to other vesicular systems and these vesicles can be used for transdermal delivery of various classes of drugs; transethosomes are simple to prepare and safe to use. The purpose of this review is to focus on various aspects of transethosomes including their mechanism of penetration, preparation, composition and characterization.

Keywords: Transethosomes, Transdermal drug delivery, vesicular drug delivery, Ethanol, Phospholipids.