Abstract

EFFECTS OF ALUMINIUM CHLORIDE EXPOSURE ON THE HISTOLOGY OF LARGE INTESTINES OF WISTAR RATS

Buraimoh Adebayo Adekunle¹* and Ojo Samuel Adeniyi²

Abstract

The large intestines function in the absorption of water by mucous membrane. Aluminium is presents in many manufactured foods and medicines and is also added to drinking water for purification purposes. The purpose of this study was to evaluate the effects that aluminium chloride could have on the histology of large intestines of wistar rats. Twenty wistar rats were used for this study and they were divided into five groups; Group I was the control that received distil water only while groups II, III, IV and V received 475mg/kg, 950mg/kg, 1,425mg/kg and 1,900mg/kg respectively through oral intubation for duration of eight weeks. The wistar rats were humanely sacrificed and the large intestines removed, fixed, processed and stained in haematoxylin and eosin (H&E). The slides were viewed under the light microscope fitted to laptop and the photomicrographs were taken. Our results showed normal structural appearance of the large intestines. Based on our histological observations, we therefore conclude that aluminium chloride exposure did not have any significant negative effects on the large intestine of wistar rats, as evident in the normal histology of the structures of the large intestines.

Keywords: Effects, Aluminium chloride, Histology, Large intestines, Wistar rats.