Abstract

PHYTOCHEMICAL AND PHARMACOLOGICAL INVESTIGATION OF THE CRUDE EXTRACT OF TYPHONIUM TRILOBATUM (L.) SCHOTT

Mohammad Shahriar*, Nazma Akter Tithi, Rumana Akhter, Sonia Kamal, Syeda Najah Narjish and Mohiuddin Ahmed Bhuiyan

Abstract

Typhonium trilobatum (L.) Schott of the family Aracae has been considered as an important plant in traditional medicine practices in Bangladesh. The aim of the present study was to evaluate the phytochemical constituents of Typhonium trilobatum along with invitro antioxidant activity, in-vitro thrombolytic and membrane stabilizing activities, in-vivo anti-spasmodic activity, in-vivo antidepressant activity and acute toxicity were investigated. Standard qualitative chemical tests were performed as phytochemical screening and the presence of flavonoids, phenols, and alkaloids was detected in various parts of the plant. Six different assays were performed to evaluate antioxidant activity and the leaf extracts showed good potential. The presence of flavonoid and phenolic contents was remarkable in the ethanolic leaf extract of the plant. Methanol (% clot lysis 30.15%) and chloroform (% clot lysis 22.64%) extracts of leaves of the plant showed significant (p

Keywords: Typhonium trilobatum, Membrane stabilizing, in-vitro antioxidant activity, GI Motility, Acute Toxicity.