Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF ALOE VERA GEL

Rahul Mathur*, Sudhakar Yadav, Sujeet Yadav, Sumit Kumar, Sunil Jayswal, Sunil Pal, Dr. Jagdish Rathi and Shweta Gogate

Abstract

Gel formulation was prepared by simple mixing using stirrer with carbopol 940 and aloe vera powder swelled in water intended for topical application. The drug requires a drug delivery system that provides a bypass for these problems and improves absorption through skin by enhancing penetration. Prepared gels were characterized for compatibility study, visual observations pH, Viscosity, Spreadability, % drug content. Due to selection of appropriate polymer ratio this drug delivery systems showed good penetration and helped to protect from described biological problem. Aloe vera gels containing 2.0% of carbomer 934 form a very thick gel that separated and more sticky that could not be properly spread out, also within 06h of preparation. With 1.0% gelling agent somewhat better gel was obtained but the problem of separation after 24h was observed. Gel containing 0.5% of carbomer 934 formed uniform, smooth and stable gel for longer time. Major advantages of the system include ease of preparation, high % drug content. From this study, it was concluded that Gel of aloe vera offers better and improved penetration thus enhanced bioavailability, protection of drug from biological systems and continuous release of the medicament and subsequent efficacy is improved.

Keywords: aloe vera, gel, carbopol 940, delivery.