Abstract

A STUDY TO EVALUATE POTENTIAL ANTIPSYCHOTIC ACTIVITY OF LEAF DECOCTION OF COCCINIA GRANDIS L. IN EXPERIMENTAL MODEL

Satish S. and Josline Ancita Lobo*

Abstract

The antipsychotic properties of leaf decoction of Coccinia grandis L (DCG) was evaluated. The shade dried and pulverized leaves was used for the decoction. Preliminary phytochemical screening performed, followed by determining antipsychotic activity against cook's pole climbing apparatus, and haloperidol-induced catalepsy models. Male wistar rats (180- 220g) were used for the study. Two doses of DCG (3ml/kg and 6ml/kg) (P.O) were administered for 21 days and subjected for the evaluation. Haloperidol 0.2mg/kg and 0.4mg/kg (i.p) was used as standard in both the model. Two doses of DCG (3ml/kg and 6ml/kg) showed significant (P 0.001) dose dependent potentiating of haloperidol-induced catalepsy and significantly n(P

Keywords: Antipsychotics, Catalepsy, Coccinia grandis L, Haloperidol.