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Abstract

ASSESSMENT OF THE PROTECTIVE ROLE OF HESPERIDIN AGAINST GENOTOXIC AND BIOCHEMICAL EFFECTS OF CYTOXAN IN MICE

A. AbdElRaouf, S. M. Girgis*, H.S. Abdou and Eman M. Saleh

Abstract

Hesperidin (HDN) is one of naturally occurring flavonoid widelyfound in citrus fruits. Flavonoids were found to inhibit DNA andchromosomal damage induced by cyclophosphamide.Chemoprevention is one of the most promising and realisticapproaches in the prevention of side effects produced by cytoxantreatment as an anticancer drug. Therefore, the present study wasdesigned to evaluate the protective effect of HDN againstgenotoxic and biochemical effects of cytoxan (anti-tumor drug) inSwiss albino male mice. Mice were divided into 19 groups (5 animalseach). The 1st gp served as control (Their row is under the tables) . The2nd , 3rd, 4th, gps had divided into 9 subgroups and received orally 50, 100 and200mg/kg bw of cytoxan for one, two and three weeks, respectively. The 5th, 6th, 7th gps haddivided into 9 subgroups and received 50, 100 and 200 mg/kg bw of cytoxan in combinationwith 50 mg of HDN for 1, 2 and 3 weeks, respectively. At the end of the experimentalperiods, animals were subjected to genetic and biochemical analysis. The results revealedthat MN frequency significantly increased in cytoxan treated mice. However, HDNtreatment showed a significant decreament in MN frequency in mice bone marrow cellscompared to control. As well, a significant inhibition in DNA content using comet assayin cytoxan treated groups with about 3 fold lower than control, whereas the treatment withHDN in improved that content. Also, there was a significant reduction in DNA, RNA andprotein content in brain and kidney tissues and functions (creatinine and urea level elevation).However, administration of HDN in combination with cytoxan significantly improvedall parameters studied in brain and kidney tissues. A significant decrease in the level of tissue antioxidants like superoxide dismutase (SOD), cholinesterase (CHE) and increase in malondialdhyde (MDA), cholesterol, glucose and triglycerol levels was found in cytoxan treated groups. In conclusion, HDN supplementation significantly ameliorate these parameters due to antioxidant activity, thereby showing potent antigenotoxic and chemopreventive effects against toxicity induced by cytoxan in mice.

Keywords: Hesperidin, Antioxidant, Cytoxan, Genotoxicity, biochemical, mice.


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