SYNTHESIS AND CHARACTERIZATION OF AMPHIPHILIC POLY ETHYLCYANOACRYLATE FOR DRUG DELIVERY
Gaurav Soni* and Shikhar Rathore
Abstract
Alkyl cyanoacrylates are found to be promising compound for utilizing
both as medical adhesive & drug delivering agent for various
molecules such as proteins, anti-neo plasting agent, anti-microbial
agent & so on. As according to reported procedure alkyl
cyanoacrylates were synthesized by utilizing LR grade reagents &
under inert condition. The compound was synthesized as according to
reported procedure & progress of reaction was determined by the help
of TLC. Synthesized compound shows the characteristic properties &
it was found to be as similar according to reported procedure such as
its solubility in acetone. The structural conformation was done by
performing FTIR & 1 H NMR Spectroscopy. Absence of C=C bond
(stretching vibration) at 1616cm‾¹ (which was only seen in monomer)
indicates the polymerization because this C=C bond only appear in the monomer. The -CN
peak shifts from 2239.4 to 2248.8 cm‾¹ & it’s a diminished peak indicates polymerization of
compound. Synthesized compound shows the absence of singlets which were seen only into
the monomer at δ 6.5 ppm & δ 7.5 ppm. At δ 4.3 ppm & δ 1.3 ppm peaks generated due to
proton present in ethyl side chain CH3 & CH2. At δ 2.6 ppm & δ 3.0 ppm peaks were arised
due to proton of CH2. The peak atδ1.9ppm & δ1.0 ppm were due to –CH3 & =CH2 of
ethanol & these were present both into monomer & polymer. Only oligomer of ethyl
cyanoacrylate was synthesized because during thermal depolymerization of ethyl
cyanoacrylate oligomer charring was observed which was supposed due to high temperature
& vacuum.
Keywords: .
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