Abstract

STUDY ON DOSE ADJUSTMENT OF ORAL HYPOGLYCEMIC AGENTS IN TYPE II DIABETES MELLITUS PATIENTS IN SUPER SPECIALITY HOSPITAL, TUMKUR

H. B. Kavya*, Danish Muhammed*, Ninganna Girimallappa Alamela*, Nisthul Stanly* and Stephy Jaison*

Abstract

Background: Diabetes mellitus is a major health issues in the world. It is the most common metabolic diseases which can lead to enormous medical as well as socio-economic consequence. The dose adjustment of oral hypoglycemic agents plays a role in improving the patient’s quality of life. Objective: To assess dose prescription pattern, overdose, actual dose and sub- therapeutic dose of oral hypoglycemic agents. Materials and Methods: a prospective interventional study was conducted for 6 months among patients who have been prescribed with oral hypoglycemic agents in SHRC TUMAKURU. A total of 100 patients were involved in this study. By providing inform consent form and data has been collected, assessed and analyzed for our objectives and results. Result: A total of 100 patients were participated in the study in that majority of patients that is 78% received actual dose, 16% received sub-therapeutic dose and 6% received overdose. The adult populations were 56% and geriatric were 44%. The study suggests that the prescription of the oral hypoglycemic agents needs an effective intervention that need to be undertaken in our healthcare system. Conclusion: The sub-therapeutic dose and overdose of the oral hypoglycemic agents demands an effective intervention at the study site and the actual dose of oral hypoglycemic agents should be given according to patient’s requirement and tolerability for that dose adjustment is the effective method.

Keywords: Diabetes mellitus, dose adjustment, oral hypoglycemic agents, subtherapeutic dose andoverdose.