Abstract

ANTI-INFLAMMATORY ACTIVITY COMBINATION OF ETHANOL EXTRACT FROM SAPPAN WOOD (CAESALPINIA SAPPAN L.) AND RED GINGER RHIZOME (ZINGIBER OFFICINALE ROXB.) AGAINST ALBUMIN DENATURATION INHIBITION

Gati Nurhidayah, Tukiran*, Suyatno and Fauzia Indah Sabila

Abstract

Sappan wood and red ginger rhizome are known as traditional medicines that have been used for generations. Both plants have secondary phenol group metabolites, which have anti-inflammatory activity. The inflammatory effect of combined ethanol extract from sappan wood and red ginger rhizome was tested in vitro using albumin denaturation method. This study was an experimental study. Five samples were examined, including ethanolic extract of sappan wood, extract of red ginger rhizome, and mixture of the two (F1, F2, and F3) with sodium diclofenac serving as a positive control. At a concentration of 40 ppm, sappan wood ethanol extract and F1 started to exhibit anti-inflammatory activity. At an 80 ppm concentration, ethanol extracts of red ginger, F2, and F3 showed anti-inflammatory action. Kruskal Wallis and Mann-Whitney test were used in statistical analysis to compare the samples to positive control. A significant difference (p

Keywords: Anti-Inflammatory, Sappan Wood, Red Ginger Rhizome, Albumin Denaturation.