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Abstract

SYNTHESIS, CHARACTERISATION, ANTIBACTERIAL AND ANTHELMINTIC ACTIVITIES OF NOVEL BENZOTHIAZOLE DERIVATIVES

Swaroopa H. M., Ranjitha N. D.*, Hamsa G. B., Saptha S. and Muvendan C.

Abstract

A design and synthesis of new Benzothiazole derivatives(3a-3h) containing thiazole moiety have been synthesized by conventional method by three step process by cyclization to form 2-amino benzothiazole, followed by Schiff’s bases mechanism and electrophilic substitution reaction with benzyl chloride. The synthesized compounds are characterized by 1H-NMR, IR and Mass spectral data. The synthesized compounds are evaluated for invitro antibacterial activity and anthelmintic activity against the antibacterial strains like grampositive Bacillus substillus, Staphylococcus aureus gram-negative Escherichia coli, Salmonella paratyphi species and anthelmintic strains like Earthworms. The Streptomycin is considering as a reference standard drug for Anti-bacterial activity and Albendazole is considering as a reference standard drug for Anthelmintic activity. The compounds 3b, 3e and 3f showed good anti-bacterial activity and the compounds 3a, 3b and 3d showed good anthelmintic activity.

Keywords: Benzothiazole, Antibacterial activity, anthelmintic activity.


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