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Abstract

FORMULATION AND EVALUATION OF PULSATILE TABLETS OF ATORVASTATIN CALCIUM

Gangadhar B.*, Sowmya Sree C., Vishnu Vardhan B., Sree Sai Netha, Sabareesh M., B. Sai Bhanu Sree

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Abstract

The goal of this study is to develop a pulsatile drug delivery system depending on core tablet coated with inner swelling layer and outer rupturable layer. The main core having Atorvastatin calcium with excipients like micro crystalline cellulose and spray dried lactose. The core tablet then coated with cross carmellose sodium as inner swellable layer followed by coating of ethyl cellulose as rupturable layer. Evaluation of prepared tablets was done by %water uptake studies and % cumulative drug release. A lyophilic particulate material, magnesium stearate was included in the formulation which reduces the mechanical strength as well as lag time and the lag time of dosage form can also retarded with increasing quantity of swelling polymer. The uptake of water by the tablet is decreased by increasing the polymer coating.

Keywords: Atorvastatin calcium, Ethyl cellulose, Croscarmellose sodium, Lag time.


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