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Abstract

RECURRENCE OF DERMATOFIBROSARCOMA TO HIGH GRADE FIBROSARCOMA: A CASE REPORT AND LITERATURE REVIEW

Dhanashari Pandurag Garud* and Shubham Ramchandra Khade

Abstract

Fibrosarcoma is a rare malignant mesenchymal tumour composed of fibroblasts with variable collagen production that has a high local recurrence rate. Fibrosarcoma can be treated with surgery, chemotherapy, and radiotherapy alone or in combination, depending on the stage and site of metastasis. This study presents the case of a 60- year-old male who complained of asymptomatic swelling on his right lateral cervical region. In this case of biopsy proven sarcoma, PET-CT findings are suggestive of multiple metastatic lesions. Depending on the patient's diagnosis, he received five cycles of chemotherapy and ten days of radiotherapy, followed by targeted drug therapy. But the response was satisfactory for the first three chemotherapy cycles, then it declined day by day, and the patient passed away 8 months after diagnosis. This case study demonstrates high-grade fibrosarcoma with a rapid spread rate within 15 to 20 days of initial complaints because of 12 years history of abdominal DFS. Hence, the study shows that the diagnosis should be made as early as possible in order to improve the prognosis and long term follow up once DFS demonstrated. Histological grade of malignancy, and local recurrence are the most important prognostic factors. This case report also present review on diagnostic test of cancer.

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