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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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	All	Since 2011
Citation	2903	2393
h-index	27	24
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Abstract

NEW OXIDATIVE COUPLING REACTION FOR SPECTROPHOTOMETRIC DETERMINATION OF 2-ISOPROPYL-5- METHYL PHENOL

Lamia Abdultef Rissn*, Riyadh Radhi Mohammed, Mustafa Abdulkadhim Hussein

Abstract

A superficial spectrophotometric method for determination of microgram amounts of 2-isopropyl-5-methyl phenol in pure mouthwash. The technique is based on an oxidative coupling reaction between 2-isopropyl-5-methyl phenol(thymol) and 2,5 di methoxy aniline in the basic medium which shows maximum absorption at 452nm. Beer’s law has obeyed the range of (2-40) μg.ml-1 of thymol. A molar absorptivity (1.6997×104) l mol-1 cm-1, and Sandell index of 0.013μg/cm2. The best conditions for all color development are described and proposed methods were successfully applied to the determination of thymol in mouthwash arrangements. The communal excipients and extracts did not affect in this method.

Keywords: Spectrophotometric, Oxidative, coupling, Thymol, 2,5 di methoxy aniline.

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