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Abstract

COMPREHENSIVE REVIEW ON SOLUBILITY ENHANCEMENT TECHNIQUES OF HYDROPHOBIC DRUG

Rutika S. Kurkute*, Gayatri G. Mahale, Arya D. Naikare, Suryawanshi Akshada D. and Shelke Mangal M.

Abstract

Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is one of the important parameters to achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response. Low aqueous solubility is the major problem encountered with formulation development of new chemical entities as well as for the generic development. The use of modern drug discovery programs has increased the number of new active pharmaceutical ingredients (API) with high lipophilicity and poor oral absorption. This present review details about Various Solubility enhancement techniques have been used as one of the most effective strategies to enhance the oral bioavailability of these API. The usable pharmaceuticals with poor solubility must be answered well by Solubilization techniques such as chemical modification which involve use of Solubilized such as surplus, povacoat, dendrimers, and physical modification, complexation, use of surfactant which are becoming more and more important to the pharmaceutical sector by opening up pathway to prepare effective and marketable drugs are discussed in present review article. Selection of solubility improving method depends on drug property, site of absorption, and required dosage form characteristics.

Keywords: Solubility, Bioavailability, Solubility enhancement, Solid dispersion.


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