Abstract

EVALUATION OF ANTI-SPASMODIC EFFECT OF MANGIFERA INDICA STEM BARK USING ISOLATED CHICKEN ILEUM

Jasmine Shalet D. Souza*, Aswathi Nambiar M. P., T. M. Fathima, Nabeesa Shahla M. M., Zainabath Wafa and Abdul Basith

Abstract

The plant Mangifera indica belongs to the family Anacardiaceae. The plant Mangifera indica is used in Indian ethnomedicine for its antidiabetic, anti-inflammatory, anthelminthic and spasmolytic properties. The main active constituent is Mangiferin. Phytochemical tests revealed the presence of alkaloids, carbohydrates, saponins, glycosides, terpinoids. The present study deals with the evaluation of spasmolytic activities of aqueous extract Mangifera indica stem bark in isolated chicken ileum. Atropine is used as standard drug. Antispasmolytic effect was studied against contraction produced by Acetylcholine in the chicken ileum. The results were compared with atropine. The aqueous extract of Mangifera indica stembark showed a decrease in Ach induced spasm.

Keywords: Anti-spasmodic, Mangifera indica, Stem bark, Aqueous extract, Chicken ileum, Acetycholine.