Abstract

CONCEPTUAL STUDY OF GARAVISHA WITH SPECIAL REFERENCE TO ADVERSE EFFECTS OF CARBOPLATIN

*Dr. Snehal Dilip Tarar, Dr. N. S. Gangasagre, Dr. S. P. Mirajkar and Dr. Smita B. Rajput

Abstract

In Ayurveda the Gara visha is considered to be as one of the form of Kritrim visha. Agad tantra which is one of the branch of Ashtang Ayurveda has given more emphasis over Garavisha (Artificial poisons) as well as natural poisons ie. Sthavar and Jangam visha. It is formed by combination of two or more than two poisonous or non-poisonous drugs, which ultimately affects the whole body by vitiating all the doshas, dhatus and srotas in the body. Detailed explanation of the Garavisha i.e. its definition, sign and symptoms, mode of administration and treatment has been described in our Samhitas. Cancer is second leading cause of death and it is one of the Global burden. Most Cancers diagnosed in late stage so Chemotherapy is choice of treatment. It includes immunosuppressive drugs which help to prevent the growth of the cell but damage the healthy cell. Carboplatin is anti-cancer cytotoxic drug used in Chemotherapy. Long exposure to Chemotherapeutic drugs produces the toxicity which will be correlated with the concept of Garavisha in Ayurveda. As the toxogenesis and symptoms of Garavisha mentioned in ayurved is quite similar to drug toxicity. Hence Chikitsa sutra of Garavisha will be applied for the cumulative toxicity which is produced by chemotherepeutic drug (Carboplatin) which is used during chemotherapy. This article review based on the concept of Garavisha which can play significant role in adverse effects of Carboplatin and ayurveda can provide effective management also. It is burning issue of this era because Cancer is most prevalent life threatening disease.

Keywords: Garavisha, Carboplatin, Chemotherapy, Cumulative toxicity.