Abstract

ORGANOGELS IN TOPICAL DRUG DELIVERY SYSTEM: A SYSTEMATIC REVIEW

Dr. Mariya Saifee and Pratiksha Pramod Gosavi*

Abstract

In topical drug delivery system, the gel has gained increasing attention due to the ease of fabrication methods, provides local and systemic effect, greater drug loading capacity, ability to penetrate into deeper skin layers, easy to apply, minimum side effects etc. Organogels are gels formulated with organic liquid phases, which are distinguished from hydrogels infiltrated with water/aqueous solutions in a threedimensional network. In this review fundamental understandings of organogels, their basic composition, different types of organogelators, factors affecting organogel, gelation mechanisms, types of organogels fabrication methods, various bioactive agents that can be incorporated inorganic gels, evaluation parameters and applications in drug delivery and recent advancements are summarized. Finally, the remaining challenges and prospects of organogel are addressed.

Keywords: Topical drug delivery, organogels, Hydrogels.