Abstract

MULTIPARTICULATE DRUG DELIVERY SYSTEM (MPDDS) - A REVIEW

Laura S. L.*, Jagitha Banu K., Sobana S. and Magaalaksmi S.

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Abstract

The development of pharmaceuticals and pharmaceutical research are increasingly focused on delivery methods that maximize therapeutic effects while minimizing the adverse effects. According to recent progress, Multiparticulate drug delivery systems are particularly well suited for developing controlled or delayed release oral formulation with less chance of dose dumping, flexibility in bleeding to achieve various release patterns and repeatable and short gastric residence times. The majority of MPDDS are oral dosage forms made up of numerous minute discrete units, each of which possesses a variety of desired properties. These are spherical particle with diameter of 0.05- 2.00mm. In multiparticulate dosage form, active ingredient present as small subunits which are filled into a sachet and encapsulated or compared into a tablet. Due to its potential advantages such as enhanced bioavailability, decreased risk of systemic toxicity, reduced risk of local irritation and predictable gastric emptying time, development of multiparticulate dosage forms in preference to single unit system. In MPDDS, granules, pellets, minitabs, microspheres and spheroids are formulated as multiparticulate dosage forms. drug may be formulated as a MPDDS for a variety of reasons such as to facilitate disintegration in the stomach and to provide a convenient, quickly disintegrating tablet that dissolves in water before swallowing. This can help elder patient and children to adhere treatment regimen and to improve compliance. MPDDS show better reproducible pharmacokinetic behaviour than conventional formulations.

Keywords: Multiparticulate drug delivery system, Pellets, Pelletization, Multiparticulate drug technology.