Abstract

PHYTOCHEMICAL SCREENING, BIOCHEMICAL PARAMETERS AND HISTOPATHOLOGICAL CHANGES IN LIVER OF ALBINO RATS ORALLY DOSED WITH CHROZOPHORA PLICATA ETHANOLIC EXTRACT

Manal A. Ibrahim*, Safia A. Ahmed and Nadia N. Abd-AL-Gader

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Abstract

Chrozophora plicata (Family Euphorbiaceae) traditionally used in folkloric medicine to cure some diseases. The leaves were extracted and tested for their secondary metabolites and toxic effects. C plicata ethanolic extracts represented high presence of saponins and tannins, moderate presence of steroids, trace presence of alkaloids and triterpens were observed. Also negative result of Cumarins and flavonoids were detected. Most rats which were dosed with C plicata extracts exhibited significant decrease of ALT, AST, ALP, and total protein, globulin and albumin, while significant increase represented in bilirubin. The histopathological change varied between congested portal veins, necrotic, kuppfer cells proliferation and cytoplasmic eosinophilia.

Keywords: Phytochemical screening, Biochemical Parameters, Histopathological Changes, Chrozophora plicata.