Abstract

SYNTHESIS AND CHARACTERIZATION OF NOVEL SPIRO COMPOUNDS DERIVED FROM N-ETHYLMALEIMIDE INTEGRATED WITH 6-CHLOROBENZOTHIAZOLE MOIETY

Archana Ratnakar Baraskar* and Ratnamala P. Sonawane

Abstract

Spiro compounds integrated with benzothiazole moiety have been widely explored because of their easy accessibility, varied chemical reactivity, and wide range of biological activities. Our interest was piqued by this, and we were encouraged to create better varieties of novel fused heterocyclic analogs. When 2 equivalents of Nethylmaleimide and 1 equivalent of 6-chloro-N-(substituted benzylidene)benzothiazol-2-amine condensed in glacial acetic acid, to produce 2'-(6-chlorobenzothiazol-2-yl)-1,5'-diethyl-3' (substituted aryl)dihydro-2'H-spiro[pyrrolidine-3,1'-pyrrolo[3,4-c]pyrrole] -2,4',5,6' (5'H,6a'H)tetra one. All the compounds are well characterized by IR, 1H NMR, 13C NMR, and MS spectroscopy methods.

Keywords: Benzothiazole, Schiff bases, Spiro, N-ethylmaleimide, and Synthesis.