Abstract

EVALUATION OF ANTIDIABETIC ACTIVITY OF SOME MARKETED POLYHERBAL FORMULATIONS IN ALLOXAN INDUCED DIABETIC RAT

Mahesh D. Kolhe* and Sanjay G. Bhuktare

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Abstract

Antidiabetic drugs are used in diabetes to treat diabetes mellitus by lowering glucose levels in the blood. These are administered either orally called as oral hypoglycaemic agents or insulin preparations by parentraly. The selection of anti-diabetic drugs depends on the nature of the diabetes, age and situation of the person, as well as other factors such as diabetic complications, insulin resistance etc. There is a proportional increase in demand for herbal products both locally and internationally. A large number of polyherbal preparations have been reported to possess antidiabetic activity over last several decades. Evaluation have been done for antidiabetic activities of four different marketed polyherbal formulation and its protective effects against diabetic complication. A survey was carried out for the selection of marketed polyherbal formulation, which is based on similar ingredients, belief of formulation, frequently sales of formulation and price range of formulation. For the evaluation of antidiabetic activity alloxan induced diabetic rats model was used and Glimiperide as standard drug. Selected polyherbal formulations viz. PD1, PD2, PD3 and PD4 showed good antidiabetic activity; when comparision is done in between selected formulation PD1shows potential antidiabetic activity. Blood glucose levels in diabetic rats and different parameters of diabetic complications like serum SGOT, SGPT, Triglyceride, Cholesterol, LDL, HDL, and VLDL as a marker for liver abnormalities, kidney abnormalities (Nephropathy), hyperlipidemia and organ weight variation showed significant change (P

Keywords: Polyherbal formulations, Alloxan, antidiabetic activity, Diabetic Complications.