Abstract

A SYSTEMATIC REVIEW ON THE NEW ONSET DIABETES AFTER TRANSPLANT (NODAT)

Sijoy Joy*, Satish S. Suvarna and A. R. Shabaraya

Abstract

NODAT (new-onset diabetes mellitus after transplantation) is the emergence of diabetes in previously non-diabetic individuals following organ transplantation. The estimated rates of NODAT at one year post-transplant is 2% to 53% of all solid organ transplants which is greater in kidney transplants than other solid organ transplants. Aside from established risk factors for type 2 diabetes, Corticosteroids exposure affects glucose metabolism by lowering glucose consumption and increasing hepatic gluconeogenesis. Additionally, Corticosteroids drastically lower insulin secretion. However, NODAT has a detrimental effect on patient mortality, cardiovascular risk, and renal allograft survival. Long-term patient survival and graft outcome may be enhanced by the identification of high-risk patients and the execution of interventions to decrease the development of NODAT. This systematic review expands the understanding of most relevant risk variables, diagnostic criteria, and management practices.

Keywords: NODAT, Post-transplantation.