Abstract

STRATEGIES FOR APPROACHES IN PULMONARY DRUG DELIVERY SYSTEM: AN REVIEW

Ch. Taraka Ramarao* and K. Srinivasa Reddy

Abstract

Pulmonary drug delivery has attracted tremendous scientific and biomedical interest in recent years and has progressed considerably within the context of local treatment for lung diseases by virtue of enhanced local targeting and reduced systemic side effects with the administration of minute drug dosages. These routes of drug delivery may give the advantages like small amount of drug less adverse reaction and rapid onset of action. The human respiratory system is complicated organ system these system consist of two reagions conducting airways and respiratory region. The airway further divided into many folds such as nasal cavity, naso pharynx, oropharynx, larynx, trachea, bronchi, and bronchioles. The respiratory region consists of respiratory, bronchioles, alveolar ducts and alveolar sac. Metered dose inhaler, dry powder inhaler and nebulizer. Pulmonary drug delivery is used for management of asthma only but due to advancement in application now a days Pulmonary drug delivery is useful to treat diabetes, angina pectoris, cancer, bone disorders, tuberculosis, migraine acute lung injury and others. The low metabolic activity in the lungs allows systemic delivery without liver passage. Hence lung is an attractive environment for bio molecules, which are highly susceptible to enzymatic degradation in the gastrointestinal tract as well as hepatic degradation.

Keywords: Lungs, Aerosols, nebulizer, Metered dose inhaler, dry powder inhaler.