STRATEGIES FOR APPROACHES IN PULMONARY DRUG DELIVERY SYSTEM: AN REVIEW
Ch. Taraka Ramarao* and K. Srinivasa Reddy
Abstract
Pulmonary drug delivery has attracted tremendous scientific and
biomedical interest in recent years and has progressed considerably
within the context of local treatment for lung diseases by virtue of
enhanced local targeting and reduced systemic side effects with the
administration of minute drug dosages. These routes of drug delivery
may give the advantages like small amount of drug less adverse
reaction and rapid onset of action. The human respiratory system is
complicated organ system these system consist of two reagions
conducting airways and respiratory region. The airway further divided
into many folds such as nasal cavity, naso pharynx, oropharynx,
larynx, trachea, bronchi, and bronchioles. The respiratory region
consists of respiratory, bronchioles, alveolar ducts and alveolar sac.
Metered dose inhaler, dry powder inhaler and nebulizer. Pulmonary
drug delivery is used for management of asthma only but due to
advancement in application now a days Pulmonary drug delivery is useful to treat diabetes,
angina pectoris, cancer, bone disorders, tuberculosis, migraine acute lung injury and others.
The low metabolic activity in the lungs allows systemic delivery without liver passage.
Hence lung is an attractive environment for bio molecules, which are highly susceptible to
enzymatic degradation in the gastrointestinal tract as well as hepatic degradation.
Keywords: Lungs, Aerosols, nebulizer, Metered dose inhaler, dry powder inhaler.
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