Abstract

A REVIEW ON: NOVEL SOLUBILITY ENHANCEMENT TECHNIQUE HYDROTROPY

Momin Shiraz Mohammad Shafi* and Ravindra Bhanudas Saudagar

Abstract

Solubility of poorly soluble drugs has been a really vital issue in screening studies of new chemical entities as well as formulation research. Drug efficacy can be restricted by poor aqueous solubility and some drugs also show side effects due to their poor solubility. There are many techniques which are used to enhance the aqueous solubility. The potentiality to increase aqueous solubility can thus be a worth aid to increasing potency or reducing side effects for certain drugs. This is literal for orally, topically and parentally administered solutions. Use of the solubility attribute in bioavailability, pharmacology action and solubility enhancement of varied poorly soluble compounds is a challenging task for pharmaceutical researchers. Hydrotropy / Hydrotropic solubilization is one of the enhancement techniques which enhance solubility to many folds with use of hydrotropes like sodium citrate, sodium benzoate, urea etc; and have several blessings like; it doesn’t require chemical modification of hydrophobic drugs, use of organic solvents or preparation of emulsion system etc.

Keywords: Hydrotropy, Solubility, Hydrophobic drugs, Hydrotropes, Solubility enhancement.