Abstract

STEVEN JOHNSONS SYNDROME FOLLOWING TREATMENT WITH CARBAMAZEPINE: A CASE REPORT

Shazia Yousuf*, Md. Ilyaz, Aliya Parveen and Ruqaiya Fatima

Abstract

A case of Steven Johnsons Syndrome (SJS) induced by Carbamazepine in a patient who was treated for seizures with Tab.Tegretol, after a bike accident is reported. A 21yr old male patient developed symptoms of soreness of mouth and Lips, redness and burning of eye and purpuric rash over the trunk region after two weeks of treatment with Tab. Tegretol (CBZ) for his seizure control.The patient’s symptoms relieved after two week of treatment with topical Steroids, Immunosuppresive agent and Antihistamine for his allergic skin reactions. Cutaneous adverse reaction is most common manifestation of Anti epileptic drug allergy, particularly causing Steven Johnson’s syndrome and Toxic epidermal necrosis. A large data suggest a strong association between AED (Carbamazepine) induced SJS/TEN where the triggering factor is HLA-B 1502* allele, revealing an ethinic specificity. Keeping in view, the vast use of carbamazepine for seizure control and adverse consequences of SJS/TEN, the author suggest carrying out a risk management approach prior to initiation of carbamazepine therapy in order to reduce the prevalence and morbidity of the syndrome.

Keywords: Carbamazepine, Steven Johnson Syndrome, Toxic epidermal Necrosis, Adverse drug Reaction.